| Artist | Title | Episode | Scene | CD |
| S.O.L.I.S. | Dolphins (Desert's Mashed Mix) | 214 | Babylon - Justin's working | x |
| Saint Pete | Can't Stop This Feeling | 506 | Gym - Ted Remembers Being The PRIDE Pitty-Fuck | x |
| Sal Dano | Come Into Me | 122 | Boys at Babylon | x |
| Sal Dano featuring Jennifer Nieves | Come With Me (Dano's Peak Hour Mix) | 122 | Boys at Babylon | x |
| Sam Roberts | Brother Down | 303 | Brian & Michael get high | x |
| Sandy B | Feel Like Singing | 112 | Diner - Justin tries to play middle man | x |
| Sarah McLachlan | Touch | 211 | Wedding Intro | x |
| Sarah McLachlan | Plenty (Fade Mix) | 219 | Aftermath / End Credits | Queer as Folk: The Second Season |
| Sasha & John Digweed featuring Jayn Hanna | Lost Without You | 210 | Ben & Michael, candlelight vigil | x |
| Satoshi Tomiie feat. Deanna | Sneaky One (Victor Calderone Original Mix) | 206 | Justin & Brian come to an agreement / End Credits | Queer as Folk: The Second Season Bloodsport |
| Schubert | Quartet No. 13 Op. 29 | 208 | Burgers in the Limo | x |
| Science Dept. featuring Erire | Breathe | 212 | Ted, Emmett, Mel and Lindsay eat at Rain | x |
| Scissor Sister | The Skins | 502 | LA Club - Justin and Conner | Queer as Folk: The Final Season |
| Secret Society | Stolen (John Selway Mix) | 408 | Kinnetic Meeting | x |
| See Spot Run | Weightless | 104 | Justin & Daphne in Justin's Room | x |
| See To Sky | Up Jumped The Boogie | 105 | Chattin' at Liberty Diner | x |
| Shannon | Give Me Tonight | 106 | Michael messed up at Babylon | x |
| Shannon McNally | Down & Dirty | 109 | Lindsay & Melanie In Bed | x |
| Sheila Chandra | Sacred Stones | 509 | Babylon - Brian Dreams | x |
| Sherrie Lean | Anyway(Hex Hector Club Mix) | 501 | Gym - Teddy's Getting Chubby | x |
| Sigur Rós | Svefn-g-englar | 202 | Brian and Justin Make Love / End Credits | Ágætis Byrjun |
| Sigur Rós | Njósnavélin (The Nothing Song) | 301 | Brian & Hustler / End Credits | () |
| Simian | Sunshine | 414 | Opening Scene - Liberty Ride | x |
| Simone Denny | Cliche (Paul Graces Big Room Mix) | 513 | Ski Lodge - Ted and Emmett - Blake is back! | x |
| Singapore Sling | Nuthin Ain't Bad | 407 | Loft - Justin trys to "spice" things for Brian. | x |
| Skindive | No More Good Guys | 201 | Brian drops off Justin / End Credits | Skindive |
| Sky | Superhero | 108 | Justin and Brian leave Justin's home | x |
| Slapheadz | Comaphobia | 211 | Brian in the tanning bed | x |
| Sloan | If It Feels Good Do It | 205 | End Credits | x |
| Smokin Joe | Feel the Rhythm | 202 | Brian talks to a shrink @ Woody's | x |
| Sneaker Pimps | Spin Spin Sugar | 119 | Interior Babylon | Queer as Folk: Club Babylon |
| Sneaker Pimps | Loretta Young Silks | 308 | Justin @ Daphne's/Missing Brian | Queer as Folk: The Third Season |
| Sofa Surfers | Sofa Rockers | 218 | Justin tries to convince Brian to have a romantic evening | x |
| Sopersound | Soft & Warm | 205 | Michael in Clown suit | x |
| SoulDecision | Faded | 202 | Brian, Justin & Daphane talk about dance at prom | x |
| soulDecision | Faded | 122 | The Prom | x |
| Soundblast | I Love | 106 | Debbie & Jennifer at Woody's | x |
| Souvernance | Havin A Good Time (Sound DeZign Kickn' Ass Mix) | 303 | Justin shows up at Canival | x |
| Speedbump | Deeper | 105 | Justin's Mom at Woody's | x |
| Speedbump | Do You Love Me | 106 | Brian & Dr. Dave at Woodys | x |
| Spiritual South | Green Gold | 513 | Gym - Emmett and Ted ~ Tad is too much! | x |
| Stan Rogers | Watching The Apples Grow | 122 | Flannel Party | x |
| Staple Singers aka The Edwin Hawkins Singers | O'Happy Day | 414 | Liberty Ride Finish | x |
| Stars | Death to Death | 414 | LA Club - Justin, Brett & Conner | x |
| Steve Angello | The Look (D. Ramirez Mix) | 506 | Babylon - Ted gives his weekly fuck list / Who's That? | x |
| Steve Angello | The Look (D. Ramirez Mix) | 506 | Babylon Backroom - Brian Gets Rejected | x |
| Steve Gray | Jazz Club | 218 | Justin & Ethan have a picnic on the floor | x |
| Steve Yanko | Gemini | 107 | David & Michael in Liberty Diner | x |
| Stickman | Stick 79 | 201 | Emmett's looking for a new roommate | x |
| Stickman | Stick 79 | 202 | Boys at Gym | x |
| Stine J | You Are My Sunshine | 507 | Brian & Justin Go Separate Ways / End Credits | x |
| Stonebridge | I Like | 111 | The Birthday Party | x |
| Suede | Attitude | 408 | End Credits | Queer As Folk: The Fourth Season |
| Sugarpussy | We Like The Music | 203 | Woody's | x |
| Sully | This Town's Called Crash | 206 | Debbie talks to Brian about Justin | x |
| Sunday's Best | The Californian | 513 | Diner - Deb tells all about press conf. - Ted repeats story to Emmett | x |
| Supa Kings | Back 'N Forth | 111 | The Birthday Party | x |
| Superpitcher | Fever | 502 | End Credits | Queer as Folk: The Final Season |
| Suzanne Palmer | Show Me (Michael T. Diamond Mix) | 301 | Back to Babylon | x |
| Syntax | Bliss | 413 | Loft - Justin packs for Liberty Ride. | x |