| Artist | Title | Episode | Scene | CD |
| D1 Music featuring Lisa Hunt | The Joint Is Jumpin'(Twisted Dee & Jayito Mix) | 504 | Babylon - Hard Hero's Night / End Credits | x |
| Da Hool | Eirchelruck | 105 | Brian and Client at Babylon | x |
| Daft Punk | One More Time | 204 | Brian's test is a success/Ted finds out | x |
| Daft Punk | Harder, Better, Faster, Stonger (Pete Heller's Stylus Remix) | 220 | Ben decides not to go away | Queer as Folk: The Second Season |
| Dagmar Peckova | Sesto's Aria from "La clemenza di Tito" by W.A. Mozart, K.621 | 106 | Ted & Roger listen to music / Ted & Roger Making out / Ted alone in bed | x |
| Dan Kircher | Just Nothing | 512 | Woody's - Em & Drew Say goodbye | x |
| Dan Sampson | Solid Gold | 413 | Moosie's - Gay Ja Vu | x |
| Danny Michel | Newton's Apple | 303 | Justin & Ethan in Apt. | x |
| Darren Glover | Resign | 119 | Interior CD store | x |
| Darren Wilsey | What's Your Name | 508 | Diner - Em, Deb and Brian | x |
| Darude | Sandstorm | 101 | Brian exits club, spots Justin | x |
| Darude | Feel The Beat (Remix) | 201 | Justin freaks out on Liberty St. | Central Energy, Vol. 10 |
| David Bowie | Boys Keep Swinging | 111 | Boys Walk Down Street / Brian alone / End Credits | x |
| David Morales & Lea-Lorien | How Would U Feel (Stereo Anthem Mix) | 504 | Woody's - Loretta & Deb Kiss | x |
| Death From Above 1979 | Romantic Rights | 505 | Justin & Daphne Babysitt JR | x |
| Debby Holiday | Dive (Chris Cox Club Anthem) | 502 | Poppers Dance Club | x |
| Debby Holiday | Half a Mile Away (Scotty K's Vocal Club Mix) | 513 | Woody's - Striper | x |
| Deborah Cox | Absolutely Not (Chanel Club Mix) | 213 | Babylon - The Angel Ball | Queer as Folk: The Second Season |
| Deborah Cox | Mr. Lonely | 308 | Babylon - Justin's looking for Brian | Ultimate Deborah Cox |
| Deep Dish | Flashdance | 508 | Woody's - Brian Is The Winner! | x |
| def.con.cound.system | Cultural Year Zero.95 (Godzilla vs. D.C.S.S.) | 115 | Leather demonstration | x |
| Delerium featuring Rani | Underwater | 210 | Emmett introduces George to the gang | Queer as Folk: The Second Season |
| Derrick Carter | Life Is Like A Circle | 106 | Ted & Emmett at Torso | x |
| Diana Krall | I'm Just A Lucky So and So | 121 | Store - Ted & Blake try clothes on | x |
| Dillon & Dickins | Queers R Doin' It | 120 | Babylon -Justin steals Brian's "prize" | x |
| Dimas & Ferrero | Tunes Of Nirvana | 509 | Babylon - Brian and Ted | x |
| Divina Devore | One Of The Girls | 213 | Divina turns the boys down | x |
| Divina Devore | Cheek to Cheek | 213 | Babylon - The Angel Ball | x |
| Divine | Native Love (Step By Step, Original) | 304 | Emmett Cooking | Queer as Folk: The Third Season |
| DJ Darkzone | Watching You (Non Vocal Club Mix) | 303 | Into to Carnival | x |
| DJ Disciple (feat. Mia Cox) | Caught Up | 213 | Babylon - Justin's wants to do it alone | Queer as Folk: The Second Season |
| DJ Ferry Corsten | Rock Your Body Rock | 411 | Babylon - Brian Meets Pendergrass | x |
| DJ LaFleche | Spanish Fly (Dee Main Mix) | 203 | Liberty St. - Brian and Michael | x |
| DJ Matt C | Go 48 (Bass Mix) | 103 | Vic lends Justin his card | x |
| DJ Matt C | The Struggle For Survival | 106 | Boys talking at Gym | x |
| DJ Prince & Justin K | Got To Have | 120 | Babylon - Fireman Dancing/Brian's a Jerk | x |
| DJ Rage | Gimme The Beat | 211 | Babylon | x |
| DJ Rhythm Presents Soul Theory | Drama (Dramatic Soul Mix) | 508 | Babylon - Brian Lets Brandon Back In / End Credits | Queer as Folk: The Final Season |
| DJ Serious | The Enlightening | 209 | Brian visits mom/basketball game | x |
| Dj Tiesto - featuring Suzanne Palmer | Loves On Fire | 301 | Babylon/Brian and Michael dance | x |
| DJ Tomcraft | The Mission | 119 | Brian gets phone call in bed | x |
| DJ Will Beats | Insanity | 503 | Babylon - Buy Ya A Drink (Justin, Brian and Ted) | x |
| Don't Cry | I Wanna Be A Cowboy Boys | 118 | Boys at Babylon | x |
| Doves | The Cedar Room | 403 | Bath House - Jen shows Brian his new office. | x |
| Doves | Ambition | 513 | Brian & Justin's Loft - Together making love. | Some Cities |
| Drag Kings | Follow That Dream | 205 | Mel & Lindsay announce the wedding / Michael follows dream | x |
| Dub Pistols | Six Million Ways To Live (Black Forest Mix) | 406 | Brian and Justin @ Babylon | x |
| DuMonde | Just Feel Free | 104 | Justin with Mom in car | x |
| Duran Duran | Sunrise (Peter Presta - Apple Jaxx Mix) | 501 | End Credits | x |
| DV Roxx | Hardcore Mutha Fucka | 502 | Babylon Re-Opens | Queer as Folk: The Final Season |
| Dvorak | Spring Song | 210 | Banquet hall - Mel & Lindsay taste food | x |
| Dwight Yoakum | Crazy Little Thing Called Love | 305 | Michael, Lindsay and Mel waiting at clinic | x |
| Dwight Yoakum | Crazy Little Thing Called Love | 305 | Michael runs to Mel & Lindsay's house | x |